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| 28.08.2022 | 16:00 | Unión de Sunchales | - | Sportivo Las Parejas | 2:1 (2:1) | |
| 19:00 | San Martín de Formosa | - | Juventud Antoniana | 4:0 (1:0) | ||
| 20:15 | Douglas Haig | - | Gimnasia y Esgrima (CdU) | 2:0 (2:0) | ||
| 20:30 | Defensores de Pronunciamiento | - | Crucero del Norte | 4:0 (3:0) | ||
| 20:30 | Gimnasia y Tiro de Salta | - | Atlético Paraná | 2:0 (0:0) | ||
| 21:00 | Defensores Belgrano (VR) | - | Juventud Unida de Gualeguaychú | 1:0 (1:0) | ||
| 23:30 | Central Norte | - | Boca Unidos | 3:1 (2:1) | ||
| 02.09.2022 | 01:00 | Sarmiento de Resistencia | - | Racing de Córdoba | 1:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sarmiento de Resistencia | 26 | 16 | 8 | 2 | 38:13 | 25 | 56 |
| 2 |
|
Racing de Córdoba | 25 | 15 | 8 | 2 | 44:14 | 30 | 53 |
| 3 |
|
San Martín de Formosa | 25 | 14 | 5 | 6 | 48:26 | 22 | 47 |
| 4 |
|
Central Norte | 25 | 13 | 8 | 4 | 36:19 | 17 | 47 |
| 5 |
|
Gimnasia y Tiro de Salta | 25 | 12 | 5 | 8 | 24:25 | -1 | 41 |
| 6 |
|
Douglas Haig | 26 | 11 | 7 | 8 | 37:25 | 12 | 40 |
| 7 |
|
Belgrano de San Francisco | 25 | 10 | 5 | 10 | 34:30 | 4 | 35 |
| 8 |
|
Sportivo Las Parejas | 26 | 9 | 8 | 9 | 27:26 | 1 | 35 |
| 9 |
|
Gimnasia y Esgrima (CdU) | 25 | 10 | 5 | 10 | 26:27 | -1 | 35 |
| 10 |
|
Juventud Antoniana | 26 | 9 | 6 | 11 | 24:34 | -10 | 33 |
| 11 |
|
Crucero del Norte | 26 | 8 | 7 | 11 | 21:36 | -15 | 31 |
| 12 |
|
Defensores Belgrano (VR) | 26 | 7 | 5 | 14 | 23:33 | -10 | 26 |
| 13 |
|
Boca Unidos | 25 | 5 | 10 | 10 | 24:30 | -6 | 25 |
| 14 |
|
Defensores de Pronunciamiento | 25 | 5 | 9 | 11 | 19:31 | -12 | 24 |
| 15 |
|
Unión de Sunchales | 25 | 6 | 5 | 14 | 25:40 | -15 | 23 |
| 16 |
|
Atlético Paraná | 26 | 5 | 7 | 14 | 20:38 | -18 | 22 |
| 17 |
|
Juventud Unida de Gualeguaychú | 25 | 5 | 4 | 16 | 22:45 | -23 | 19 |
| Play-off |
