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| 17.06.2022 | 20:30 | Boca Unidos | - | Gimnasia y Tiro de Salta | 0:2 (0:2) | |
| 20:30 | Sarmiento de Resistencia | - | Defensores Belgrano (VR) | 3:1 (2:0) | ||
| 20:45 | Juventud Unida de Gualeguaychú | - | Unión de Sunchales | 2:1 (0:0) | ||
| 18.06.2022 | 20:00 | Gimnasia y Esgrima (CdU) | - | Defensores de Pronunciamiento | 4:1 (1:1) | |
| 20:30 | Crucero del Norte | - | Sportivo Las Parejas | 0:2 (0:0) | ||
| 20:30 | Belgrano de San Francisco | - | Central Norte | 0:1 (0:1) | ||
| 19.06.2022 | 01:00 | Juventud Antoniana | - | Atlético Paraná | 1:1 (0:0) | |
| 20:30 | Racing de Córdoba | - | San Martín de Formosa | 4:1 (2:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing de Córdoba | 13 | 9 | 4 | 0 | 24:4 | 20 | 31 |
| 2 |
|
Central Norte | 13 | 7 | 5 | 1 | 16:6 | 10 | 26 |
| 3 |
|
Sarmiento de Resistencia | 13 | 6 | 6 | 1 | 14:4 | 10 | 24 |
| 4 |
|
Crucero del Norte | 14 | 6 | 4 | 4 | 15:19 | -4 | 22 |
| 5 |
|
Douglas Haig | 13 | 6 | 3 | 4 | 17:9 | 8 | 21 |
| 6 |
|
San Martín de Formosa | 13 | 6 | 3 | 4 | 18:12 | 6 | 21 |
| 7 |
|
Sportivo Las Parejas | 13 | 6 | 3 | 4 | 16:13 | 3 | 21 |
| 8 |
|
Gimnasia y Tiro de Salta | 13 | 6 | 2 | 5 | 11:11 | 0 | 20 |
| 9 |
|
Gimnasia y Esgrima (CdU) | 13 | 4 | 4 | 5 | 13:15 | -2 | 16 |
| 10 |
|
Belgrano de San Francisco | 13 | 4 | 3 | 6 | 10:13 | -3 | 15 |
| 11 |
|
Unión de Sunchales | 13 | 4 | 3 | 6 | 13:17 | -4 | 15 |
| 12 |
|
Boca Unidos | 13 | 3 | 5 | 5 | 10:16 | -6 | 14 |
| 13 |
|
Defensores de Pronunciamiento | 13 | 3 | 4 | 6 | 9:16 | -7 | 13 |
| 14 |
|
Juventud Antoniana | 14 | 3 | 4 | 7 | 7:17 | -10 | 13 |
| 15 |
|
Defensores Belgrano (VR) | 14 | 3 | 3 | 8 | 14:19 | -5 | 12 |
| 16 |
|
Atlético Paraná | 13 | 2 | 5 | 6 | 10:14 | -4 | 11 |
| 17 |
|
Juventud Unida de Gualeguaychú | 13 | 3 | 1 | 9 | 10:22 | -12 | 10 |
| Play-off |
