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| 04.09.2021 | 21:00 | Gimnasia y Esgrima (CdU) | - | Gimnasia y Tiro de Salta | 0:1 (0:1) | |
| 05.09.2021 | 16:00 | Crucero del Norte | - | Defensores Belgrano (VR) | 1:1 (0:0) | |
| 16:00 | Douglas Haig | - | Juventud Unida de Gualeguaychú | 0:1 (0:0) | ||
| 16:30 | Racing de Córdoba | - | Sarmiento de Resistencia | 3:2 (1:0) | ||
| 16:30 | Sportivo Las Parejas | - | Boca Unidos | 1:1 (1:1) | ||
| 23:30 | Chaco For Ever | - | Belgrano de San Francisco | 2:0 (1:0) | ||
| 06.09.2021 | 00:00 | Central Norte | - | Defensores de Pronunciamiento | 2:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing de Córdoba | 20 | 12 | 6 | 2 | 29:8 | 21 | 42 |
| 2 |
|
Gimnasia y Tiro de Salta | 20 | 12 | 6 | 2 | 25:12 | 13 | 42 |
| 3 |
|
Central Norte | 20 | 8 | 10 | 2 | 29:17 | 12 | 34 |
| 4 |
|
Chaco For Ever | 20 | 8 | 8 | 4 | 26:17 | 9 | 32 |
| 5 |
|
Sportivo Las Parejas | 19 | 6 | 7 | 6 | 20:19 | 1 | 25 |
| 6 |
|
Boca Unidos | 20 | 5 | 10 | 5 | 27:27 | 0 | 25 |
| 7 |
|
Juventud Unida de Gualeguaychú | 20 | 6 | 7 | 7 | 21:24 | -3 | 25 |
| 8 |
|
Sarmiento de Resistencia | 20 | 6 | 6 | 8 | 27:30 | -3 | 24 |
| 9 |
|
Defensores de Pronunciamiento | 19 | 5 | 8 | 6 | 20:22 | -2 | 23 |
| 10 |
|
Unión de Sunchales | 19 | 5 | 8 | 6 | 19:21 | -2 | 23 |
| 11 |
|
Defensores Belgrano (VR) | 19 | 6 | 4 | 9 | 23:29 | -6 | 22 |
| 12 |
|
Gimnasia y Esgrima (CdU) | 19 | 6 | 3 | 10 | 16:26 | -10 | 21 |
| 13 |
|
Belgrano de San Francisco | 20 | 3 | 9 | 8 | 19:28 | -9 | 18 |
| 14 |
|
Crucero del Norte | 20 | 4 | 6 | 10 | 15:30 | -15 | 18 |
| 15 |
|
Douglas Haig | 19 | 4 | 4 | 11 | 8:14 | -6 | 16 |
| Play-off | |
| Prochaine phase |
