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| 25.08.2021 | 20:00 | Crucero del Norte | - | Belgrano de San Francisco | 0:0 (0:0) | |
| 20:00 | Central Norte | - | Sarmiento de Resistencia | 3:0 (0:0) | ||
| 20:00 | Racing de Córdoba | - | Juventud Unida de Gualeguaychú | 2:0 (1:0) | ||
| 20:00 | Douglas Haig | - | Sportivo Las Parejas | 1:0 (0:0) | ||
| 20:30 | Unión de Sunchales | - | Defensores de Pronunciamiento | 2:1 (1:0) | ||
| 20:30 | Gimnasia y Esgrima (CdU) | - | Boca Unidos | 2:2 (1:1) | ||
| 21:00 | Chaco For Ever | - | Gimnasia y Tiro de Salta | 0:1 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing de Córdoba | 18 | 11 | 5 | 2 | 26:6 | 20 | 38 |
| 2 |
|
Gimnasia y Tiro de Salta | 18 | 11 | 5 | 2 | 24:12 | 12 | 38 |
| 3 |
|
Central Norte | 18 | 6 | 10 | 2 | 25:17 | 8 | 28 |
| 4 |
|
Chaco For Ever | 18 | 7 | 7 | 4 | 23:16 | 7 | 28 |
| 5 |
|
Sportivo Las Parejas | 18 | 6 | 6 | 6 | 19:18 | 1 | 24 |
| 6 |
|
Sarmiento de Resistencia | 18 | 6 | 5 | 7 | 24:26 | -2 | 23 |
| 7 |
|
Defensores de Pronunciamiento | 17 | 5 | 7 | 5 | 19:19 | 0 | 22 |
| 8 |
|
Unión de Sunchales | 18 | 5 | 7 | 6 | 19:21 | -2 | 22 |
| 9 |
|
Boca Unidos | 18 | 4 | 9 | 5 | 25:26 | -1 | 21 |
| 10 |
|
Gimnasia y Esgrima (CdU) | 17 | 6 | 3 | 8 | 14:21 | -7 | 21 |
| 11 |
|
Defensores Belgrano (VR) | 17 | 6 | 2 | 9 | 22:28 | -6 | 20 |
| 12 |
|
Juventud Unida de Gualeguaychú | 18 | 4 | 7 | 7 | 16:22 | -6 | 19 |
| 13 |
|
Belgrano de San Francisco | 18 | 3 | 9 | 6 | 19:24 | -5 | 18 |
| 14 |
|
Douglas Haig | 17 | 4 | 4 | 9 | 8:12 | -4 | 16 |
| 15 |
|
Crucero del Norte | 18 | 4 | 4 | 10 | 13:28 | -15 | 16 |
| Play-off | |
| Prochaine phase |
