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| 15.10.2022 | 15:00 | Unión de Santa Fe II | - | Atlético Tucumán II | 3:0 (1:0) | |
| 16.10.2022 | 15:00 | Rosario Central II | - | River Plate II | 3:3 (3:3) | |
| 15:00 | Platense II | - | Huracán II | 1:3 (1:0) | ||
| 15:00 | Barracas Central II | - | Arsenal de Sarandí II | 1:0 (1:0) | ||
| 17.10.2022 | 15:00 | Banfield II | - | Independiente II | 0:0 (0:0) | |
| 16:00 | Defensa y Justicia II | - | Colón de Santa Fe II | 0:1 (0:0) | ||
| 16:00 | Racing Club II | - | Lanús II | 3:1 (1:0) | ||
| 16:00 | Tigre II | - | Central Córdoba SdE II | 1:0 (1:0) | ||
| 18.10.2022 | 15:00 | Estudiantes II | - | Vélez Sarsfield II | 1:2 (1:0) | |
| 16:00 | Patronato de Paraná II | - | Godoy Cruz II | 0:0 (0:0) | ||
| 16:00 | Argentinos Juniors II | - | Gimnasia de La Plata II | 1:1 (0:1) | ||
| 16:00 | Talleres de Córdoba II | - | Aldosivi II | 2:3 (1:2) | ||
| 16:00 | San Lorenzo II | - | Sarmiento de Junín II | 0:0 (0:0) | ||
| 17:00 | Boca Juniors II | - | Newell's Old Boys II | 2:1 (1:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boca Juniors II | 26 | 17 | 3 | 6 | 45:20 | 25 | 54 |
| 2 |
|
Vélez Sarsfield II | 26 | 17 | 2 | 7 | 46:18 | 28 | 53 |
| 3 |
|
Tigre II | 26 | 13 | 8 | 5 | 33:25 | 8 | 47 |
| 4 |
|
Huracán II | 26 | 14 | 3 | 9 | 52:39 | 13 | 45 |
| 5 |
|
River Plate II | 26 | 14 | 2 | 10 | 30:27 | 3 | 44 |
| 6 |
|
Independiente II | 26 | 12 | 7 | 7 | 39:28 | 11 | 43 |
| 7 |
|
Argentinos Juniors II | 26 | 11 | 10 | 5 | 36:25 | 11 | 43 |
| 8 |
|
Newell's Old Boys II | 26 | 11 | 8 | 7 | 34:27 | 7 | 41 |
| 9 |
|
Lanús II | 26 | 12 | 5 | 9 | 41:41 | 0 | 41 |
| 10 |
|
Gimnasia de La Plata II | 26 | 11 | 7 | 8 | 45:33 | 12 | 40 |
| 11 |
|
Rosario Central II | 26 | 10 | 8 | 8 | 46:36 | 10 | 38 |
| 12 |
|
Defensa y Justicia II | 26 | 11 | 5 | 10 | 27:31 | -4 | 38 |
| 13 |
|
Talleres de Córdoba II | 26 | 11 | 4 | 11 | 41:37 | 4 | 37 |
| 14 |
|
Unión de Santa Fe II | 26 | 9 | 9 | 8 | 24:22 | 2 | 36 |
| 15 |
|
Colón de Santa Fe II | 26 | 9 | 9 | 8 | 35:35 | 0 | 36 |
| 16 |
|
San Lorenzo II | 26 | 10 | 4 | 12 | 30:32 | -2 | 34 |
| 17 |
|
Godoy Cruz II | 26 | 8 | 8 | 10 | 33:34 | -1 | 32 |
| 18 |
|
Platense II | 26 | 7 | 11 | 8 | 25:26 | -1 | 32 |
| 19 |
|
Banfield II | 26 | 8 | 7 | 11 | 24:31 | -7 | 31 |
| 20 |
|
Racing Club II | 26 | 7 | 9 | 10 | 35:32 | 3 | 30 |
| 21 |
|
Estudiantes II | 26 | 7 | 9 | 10 | 23:28 | -5 | 30 |
| 22 |
|
Arsenal de Sarandí II | 26 | 6 | 11 | 9 | 24:26 | -2 | 29 |
| 23 |
|
Sarmiento de Junín II | 26 | 8 | 5 | 13 | 20:37 | -17 | 29 |
| 24 |
|
Central Córdoba SdE II | 26 | 7 | 6 | 13 | 22:37 | -15 | 27 |
| 25 |
|
Aldosivi II | 26 | 7 | 4 | 15 | 35:53 | -18 | 25 |
| 26 |
|
Atlético Tucumán II | 26 | 6 | 5 | 15 | 29:44 | -15 | 23 |
| 27 |
|
Barracas Central II | 26 | 7 | 2 | 17 | 18:47 | -29 | 23 |
| 28 |
|
Patronato de Paraná II | 26 | 5 | 7 | 14 | 19:40 | -21 | 22 |
