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| 24.08.2021 | 19:15 | Patronato de Paraná | - | Banfield | 1:1 (1:0) | |
| 21:30 | Colón de Santa Fe | - | Sarmiento de Junín | 1:1 (0:1) | ||
| 23:45 | Atlético Tucumán | - | Independiente | 2:0 (0:0) | ||
| 25.08.2021 | 02:00 | Racing Club | - | Central Córdoba SdE | 0:0 (0:0) | |
| 19:15 | Rosario Central | - | Arsenal de Sarandí | 4:0 (4:0) | ||
| 21:30 | Lanús | - | Gimnasia de La Plata | 2:0 (2:0) | ||
| 21:30 | Defensa y Justicia | - | Newell's Old Boys | 2:0 (0:0) | ||
| 23:45 | Huracán | - | Vélez Sarsfield | 1:1 (1:0) | ||
| 26.08.2021 | 02:00 | Platense | - | Boca Juniors | 1:3 (1:1) | |
| 19:15 | Godoy Cruz | - | Unión de Santa Fe | 1:2 (1:1) | ||
| 21:30 | Argentinos Juniors | - | Talleres de Córdoba | 1:2 (0:1) | ||
| 23:45 | Estudiantes | - | San Lorenzo | 2:0 (1:0) | ||
| 27.08.2021 | 02:00 | River Plate | - | Aldosivi | 2:0 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Estudiantes | 8 | 5 | 1 | 2 | 15:7 | 8 | 16 |
| 2 |
|
Talleres de Córdoba | 8 | 5 | 1 | 2 | 12:7 | 5 | 16 |
| 3 |
|
Lanús | 8 | 5 | 1 | 2 | 16:13 | 3 | 16 |
| 4 |
|
Racing Club | 8 | 4 | 3 | 1 | 8:1 | 7 | 15 |
| 5 |
|
Independiente | 8 | 4 | 3 | 1 | 7:4 | 3 | 15 |
| 6 |
|
River Plate | 8 | 4 | 2 | 2 | 15:6 | 9 | 14 |
| 7 |
|
Colón de Santa Fe | 8 | 4 | 2 | 2 | 8:10 | -2 | 14 |
| 8 |
|
Aldosivi | 8 | 4 | 1 | 3 | 9:9 | 0 | 13 |
| 9 |
|
Patronato de Paraná | 8 | 3 | 3 | 2 | 8:6 | 2 | 12 |
| 10 |
|
Argentinos Juniors | 8 | 3 | 3 | 2 | 7:5 | 2 | 12 |
| 11 |
|
Defensa y Justicia | 8 | 3 | 2 | 3 | 11:9 | 2 | 11 |
| 12 |
|
Newell's Old Boys | 8 | 3 | 2 | 3 | 9:10 | -1 | 11 |
| 13 |
|
Atlético Tucumán | 8 | 3 | 2 | 3 | 9:11 | -2 | 11 |
| 14 |
|
Boca Juniors | 8 | 2 | 4 | 2 | 6:6 | 0 | 10 |
| 15 |
|
Godoy Cruz | 8 | 3 | 1 | 4 | 10:12 | -2 | 10 |
| 16 |
|
Sarmiento de Junín | 8 | 3 | 1 | 4 | 8:11 | -3 | 10 |
| 17 |
|
Unión de Santa Fe | 8 | 2 | 3 | 3 | 9:10 | -1 | 9 |
| 18 |
|
Gimnasia de La Plata | 8 | 2 | 3 | 3 | 7:9 | -2 | 9 |
| 19 |
|
Huracán | 8 | 1 | 5 | 2 | 6:7 | -1 | 8 |
| 20 |
|
Banfield | 8 | 1 | 5 | 2 | 5:7 | -2 | 8 |
| 21 |
|
San Lorenzo | 8 | 2 | 2 | 4 | 5:11 | -6 | 8 |
| 22 |
|
Rosario Central | 8 | 2 | 1 | 5 | 9:9 | 0 | 7 |
| 23 |
|
Vélez Sarsfield | 8 | 1 | 4 | 3 | 6:6 | 0 | 7 |
| 24 |
|
Central Córdoba SdE | 8 | 1 | 4 | 3 | 7:9 | -2 | 7 |
| 25 |
|
Platense | 8 | 1 | 3 | 4 | 8:12 | -4 | 6 |
| 26 |
|
Arsenal de Sarandí | 8 | 1 | 2 | 5 | 5:18 | -13 | 5 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
