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| 30.10.2021 | 00:00 | Racing Club | - | Defensa y Justicia | 1:2 (0:0) | |
| 02:15 | Argentinos Juniors | - | Lanús | 0:1 (0:1) | ||
| 20:45 | Arsenal de Sarandí | - | Sarmiento de Junín | 1:0 (0:0) | ||
| 20:45 | Platense | - | Atlético Tucumán | 4:1 (1:1) | ||
| 23:00 | Banfield | - | Vélez Sarsfield | 2:1 (0:1) | ||
| 23:00 | Talleres de Córdoba | - | Huracán | 1:0 (1:0) | ||
| 31.10.2021 | 01:15 | Boca Juniors | - | Gimnasia de La Plata | 0:1 (0:1) | |
| 19:45 | San Lorenzo | - | Godoy Cruz | 1:0 (1:0) | ||
| 19:45 | Unión de Santa Fe | - | Rosario Central | 3:1 (2:1) | ||
| 22:00 | Newell's Old Boys | - | Independiente | 1:0 (0:0) | ||
| 01.11.2021 | 00:15 | Estudiantes | - | River Plate | 1:1 (0:1) | |
| 23:00 | Patronato de Paraná | - | Colón de Santa Fe | 2:0 (2:0) | ||
| 02.11.2021 | 01:15 | Central Córdoba SdE | - | Aldosivi | 0:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
River Plate | 19 | 13 | 4 | 2 | 38:13 | 25 | 43 |
| 2 |
|
Talleres de Córdoba | 19 | 11 | 3 | 5 | 28:19 | 9 | 36 |
| 3 |
|
Lanús | 19 | 10 | 4 | 5 | 34:29 | 5 | 34 |
| 4 |
|
Vélez Sarsfield | 19 | 8 | 7 | 4 | 27:15 | 12 | 31 |
| 5 |
|
Defensa y Justicia | 19 | 8 | 7 | 4 | 27:18 | 9 | 31 |
| 6 |
|
Boca Juniors | 19 | 8 | 6 | 5 | 21:16 | 5 | 30 |
| 7 |
|
Colón de Santa Fe | 19 | 8 | 5 | 6 | 16:22 | -6 | 29 |
| 8 |
|
Estudiantes | 19 | 7 | 7 | 5 | 28:21 | 7 | 28 |
| 9 |
|
Huracán | 19 | 7 | 7 | 5 | 18:15 | 3 | 28 |
| 10 |
|
Independiente | 19 | 7 | 7 | 5 | 19:17 | 2 | 28 |
| 11 |
|
Gimnasia de La Plata | 19 | 7 | 7 | 5 | 17:18 | -1 | 28 |
| 12 |
|
Godoy Cruz | 19 | 7 | 5 | 7 | 28:24 | 4 | 26 |
| 13 |
|
Unión de Santa Fe | 19 | 7 | 4 | 8 | 23:26 | -3 | 25 |
| 14 |
|
Rosario Central | 19 | 7 | 3 | 9 | 27:28 | -1 | 24 |
| 15 |
|
Argentinos Juniors | 19 | 6 | 6 | 7 | 18:19 | -1 | 24 |
| 16 |
|
Racing Club | 19 | 5 | 8 | 6 | 16:14 | 2 | 23 |
| 17 |
|
Platense | 19 | 5 | 8 | 6 | 24:23 | 1 | 23 |
| 18 |
|
Sarmiento de Junín | 19 | 6 | 5 | 8 | 21:23 | -2 | 23 |
| 19 |
|
Atlético Tucumán | 19 | 5 | 6 | 8 | 20:30 | -10 | 21 |
| 20 |
|
Aldosivi | 19 | 6 | 3 | 10 | 19:30 | -11 | 21 |
| 21 |
|
Patronato de Paraná | 19 | 4 | 8 | 7 | 20:24 | -4 | 20 |
| 22 |
|
Newell's Old Boys | 19 | 5 | 5 | 9 | 19:26 | -7 | 20 |
| 23 |
|
San Lorenzo | 19 | 5 | 5 | 9 | 17:25 | -8 | 20 |
| 24 |
|
Banfield | 19 | 3 | 9 | 7 | 15:22 | -7 | 18 |
| 25 |
|
Arsenal de Sarandí | 19 | 3 | 7 | 9 | 8:23 | -15 | 16 |
| 26 |
|
Central Córdoba SdE | 19 | 2 | 8 | 9 | 18:26 | -8 | 14 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
