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| 23.10.2021 | 20:45 | Gimnasia de La Plata | - | Central Córdoba SdE | 2:2 (0:1) | |
| 23:00 | Defensa y Justicia | - | Platense | 2:1 (0:0) | ||
| 24.10.2021 | 01:15 | Rosario Central | - | Racing Club | 2:1 (0:0) | |
| 20:45 | Godoy Cruz | - | Banfield | 2:1 (1:0) | ||
| 20:45 | Colón de Santa Fe | - | Estudiantes | 2:1 (1:1) | ||
| 23:00 | Huracán | - | San Lorenzo | 2:1 (0:0) | ||
| 25.10.2021 | 01:15 | Vélez Sarsfield | - | Boca Juniors | 2:0 (1:0) | |
| 19:30 | Aldosivi | - | Arsenal de Sarandí | 2:1 (1:1) | ||
| 19:30 | Sarmiento de Junín | - | Newell's Old Boys | 2:1 (1:0) | ||
| 21:45 | Atlético Tucumán | - | Patronato de Paraná | 2:2 (1:1) | ||
| 21:45 | Lanús | - | Talleres de Córdoba | 3:3 (1:3) | ||
| 26.10.2021 | 00:00 | River Plate | - | Argentinos Juniors | 3:0 (1:0) | |
| 02:15 | Independiente | - | Unión de Santa Fe | 1:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
River Plate | 18 | 13 | 3 | 2 | 37:12 | 25 | 42 |
| 2 |
|
Talleres de Córdoba | 18 | 10 | 3 | 5 | 27:19 | 8 | 33 |
| 3 |
|
Vélez Sarsfield | 18 | 8 | 7 | 3 | 26:13 | 13 | 31 |
| 4 |
|
Lanús | 18 | 9 | 4 | 5 | 33:29 | 4 | 31 |
| 5 |
|
Boca Juniors | 18 | 8 | 6 | 4 | 21:15 | 6 | 30 |
| 6 |
|
Colón de Santa Fe | 18 | 8 | 5 | 5 | 16:20 | -4 | 29 |
| 7 |
|
Defensa y Justicia | 18 | 7 | 7 | 4 | 25:17 | 8 | 28 |
| 8 |
|
Huracán | 18 | 7 | 7 | 4 | 18:14 | 4 | 28 |
| 9 |
|
Independiente | 18 | 7 | 7 | 4 | 19:16 | 3 | 28 |
| 10 |
|
Estudiantes | 18 | 7 | 6 | 5 | 27:20 | 7 | 27 |
| 11 |
|
Godoy Cruz | 18 | 7 | 5 | 6 | 28:23 | 5 | 26 |
| 12 |
|
Gimnasia de La Plata | 18 | 6 | 7 | 5 | 16:18 | -2 | 25 |
| 13 |
|
Rosario Central | 18 | 7 | 3 | 8 | 26:25 | 1 | 24 |
| 14 |
|
Argentinos Juniors | 18 | 6 | 6 | 6 | 18:18 | 0 | 24 |
| 15 |
|
Racing Club | 18 | 5 | 8 | 5 | 15:12 | 3 | 23 |
| 16 |
|
Sarmiento de Junín | 18 | 6 | 5 | 7 | 21:22 | -1 | 23 |
| 17 |
|
Unión de Santa Fe | 18 | 6 | 4 | 8 | 20:25 | -5 | 22 |
| 18 |
|
Atlético Tucumán | 18 | 5 | 6 | 7 | 19:26 | -7 | 21 |
| 19 |
|
Platense | 18 | 4 | 8 | 6 | 20:22 | -2 | 20 |
| 20 |
|
Aldosivi | 18 | 6 | 2 | 10 | 19:30 | -11 | 20 |
| 21 |
|
Patronato de Paraná | 18 | 3 | 8 | 7 | 18:24 | -6 | 17 |
| 22 |
|
Newell's Old Boys | 18 | 4 | 5 | 9 | 18:26 | -8 | 17 |
| 23 |
|
San Lorenzo | 18 | 4 | 5 | 9 | 16:25 | -9 | 17 |
| 24 |
|
Banfield | 18 | 2 | 9 | 7 | 13:21 | -8 | 15 |
| 25 |
|
Central Córdoba SdE | 18 | 2 | 7 | 9 | 18:26 | -8 | 13 |
| 26 |
|
Arsenal de Sarandí | 18 | 2 | 7 | 9 | 7:23 | -16 | 13 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
