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| 19.10.2021 | 19:30 | Platense | - | Rosario Central | 1:1 (1:1) | |
| 21:45 | Unión de Santa Fe | - | Racing Club | 1:1 (0:0) | ||
| 20.10.2021 | 00:00 | Patronato de Paraná | - | Defensa y Justicia | 3:3 (2:2) | |
| 02:15 | Central Córdoba SdE | - | Vélez Sarsfield | 1:2 (1:1) | ||
| 19:30 | Arsenal de Sarandí | - | Gimnasia de La Plata | 0:1 (0:0) | ||
| 21:45 | San Lorenzo | - | Lanús | 1:3 (1:1) | ||
| 21.10.2021 | 00:00 | Banfield | - | Huracán | 1:4 (0:1) | |
| 00:00 | Estudiantes | - | Atlético Tucumán | 1:1 (0:1) | ||
| 02:15 | Boca Juniors | - | Godoy Cruz | 2:1 (2:1) | ||
| 19:30 | Argentinos Juniors | - | Colón de Santa Fe | 3:1 (1:1) | ||
| 21:45 | Newell's Old Boys | - | Aldosivi | 0:0 (0:0) | ||
| 22.10.2021 | 00:00 | Independiente | - | Sarmiento de Junín | 1:1 (1:1) | |
| 02:15 | Talleres de Córdoba | - | River Plate | 0:2 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
River Plate | 17 | 12 | 3 | 2 | 34:12 | 22 | 39 |
| 2 |
|
Talleres de Córdoba | 17 | 10 | 2 | 5 | 24:16 | 8 | 32 |
| 3 |
|
Boca Juniors | 17 | 8 | 6 | 3 | 21:13 | 8 | 30 |
| 4 |
|
Lanús | 17 | 9 | 3 | 5 | 30:26 | 4 | 30 |
| 5 |
|
Vélez Sarsfield | 17 | 7 | 7 | 3 | 24:13 | 11 | 28 |
| 6 |
|
Estudiantes | 17 | 7 | 6 | 4 | 26:18 | 8 | 27 |
| 7 |
|
Colón de Santa Fe | 17 | 7 | 5 | 5 | 14:19 | -5 | 26 |
| 8 |
|
Defensa y Justicia | 17 | 6 | 7 | 4 | 23:16 | 7 | 25 |
| 9 |
|
Huracán | 17 | 6 | 7 | 4 | 16:13 | 3 | 25 |
| 10 |
|
Independiente | 17 | 6 | 7 | 4 | 18:16 | 2 | 25 |
| 11 |
|
Argentinos Juniors | 17 | 6 | 6 | 5 | 18:15 | 3 | 24 |
| 12 |
|
Gimnasia de La Plata | 17 | 6 | 6 | 5 | 14:16 | -2 | 24 |
| 13 |
|
Godoy Cruz | 17 | 6 | 5 | 6 | 26:22 | 4 | 23 |
| 14 |
|
Racing Club | 17 | 5 | 8 | 4 | 14:10 | 4 | 23 |
| 15 |
|
Unión de Santa Fe | 17 | 6 | 4 | 7 | 20:24 | -4 | 22 |
| 16 |
|
Rosario Central | 17 | 6 | 3 | 8 | 24:24 | 0 | 21 |
| 17 |
|
Platense | 17 | 4 | 8 | 5 | 19:20 | -1 | 20 |
| 18 |
|
Sarmiento de Junín | 17 | 5 | 5 | 7 | 19:21 | -2 | 20 |
| 19 |
|
Atlético Tucumán | 17 | 5 | 5 | 7 | 17:24 | -7 | 20 |
| 20 |
|
Newell's Old Boys | 17 | 4 | 5 | 8 | 17:24 | -7 | 17 |
| 21 |
|
San Lorenzo | 17 | 4 | 5 | 8 | 15:23 | -8 | 17 |
| 22 |
|
Aldosivi | 17 | 5 | 2 | 10 | 17:29 | -12 | 17 |
| 23 |
|
Patronato de Paraná | 17 | 3 | 7 | 7 | 16:22 | -6 | 16 |
| 24 |
|
Banfield | 17 | 2 | 9 | 6 | 12:19 | -7 | 15 |
| 25 |
|
Arsenal de Sarandí | 17 | 2 | 7 | 8 | 6:21 | -15 | 13 |
| 26 |
|
Central Córdoba SdE | 17 | 2 | 6 | 9 | 16:24 | -8 | 12 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
