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| 02.10.2021 | 00:00 | Aldosivi | - | Unión de Santa Fe | 1:2 (1:1) | |
| 02:15 | Lanús | - | Central Córdoba SdE | 2:1 (1:1) | ||
| 18:30 | Godoy Cruz | - | Newell's Old Boys | 2:2 (0:2) | ||
| 18:30 | Platense | - | Patronato de Paraná | 0:0 (0:0) | ||
| 20:45 | Huracán | - | Arsenal de Sarandí | 1:0 (1:0) | ||
| 23:00 | Atlético Tucumán | - | San Lorenzo | 0:0 (0:0) | ||
| 03.10.2021 | 01:15 | Vélez Sarsfield | - | Independiente | 3:3 (1:2) | |
| 18:30 | Gimnasia de La Plata | - | Sarmiento de Junín | 0:1 (0:1) | ||
| 18:30 | Rosario Central | - | Argentinos Juniors | 0:1 (0:0) | ||
| 22:00 | River Plate | - | Boca Juniors | 2:1 (2:0) | ||
| 04.10.2021 | 01:15 | Racing Club | - | Estudiantes | 1:1 (0:0) | |
| 23:00 | Defensa y Justicia | - | Talleres de Córdoba | 3:0 (2:0) | ||
| 05.10.2021 | 01:15 | Colón de Santa Fe | - | Banfield | 0:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
River Plate | 14 | 9 | 3 | 2 | 28:11 | 17 | 30 |
| 2 |
|
Talleres de Córdoba | 14 | 9 | 2 | 3 | 22:13 | 9 | 29 |
| 3 |
|
Lanús | 14 | 8 | 2 | 4 | 24:20 | 4 | 26 |
| 4 |
|
Estudiantes | 14 | 7 | 4 | 3 | 22:13 | 9 | 25 |
| 5 |
|
Independiente | 14 | 6 | 5 | 3 | 16:13 | 3 | 23 |
| 6 |
|
Vélez Sarsfield | 14 | 5 | 6 | 3 | 20:11 | 9 | 21 |
| 7 |
|
Godoy Cruz | 14 | 6 | 3 | 5 | 25:20 | 5 | 21 |
| 8 |
|
Argentinos Juniors | 14 | 5 | 6 | 3 | 12:8 | 4 | 21 |
| 9 |
|
Boca Juniors | 14 | 5 | 6 | 3 | 12:10 | 2 | 21 |
| 10 |
|
Colón de Santa Fe | 14 | 5 | 5 | 4 | 10:15 | -5 | 20 |
| 11 |
|
Racing Club | 14 | 4 | 7 | 3 | 11:7 | 4 | 19 |
| 12 |
|
Huracán | 14 | 4 | 7 | 3 | 10:8 | 2 | 19 |
| 13 |
|
Defensa y Justicia | 14 | 4 | 6 | 4 | 16:12 | 4 | 18 |
| 14 |
|
Unión de Santa Fe | 14 | 5 | 3 | 6 | 14:18 | -4 | 18 |
| 15 |
|
San Lorenzo | 14 | 4 | 5 | 5 | 12:15 | -3 | 17 |
| 16 |
|
Gimnasia de La Plata | 14 | 4 | 5 | 5 | 11:15 | -4 | 17 |
| 17 |
|
Rosario Central | 14 | 5 | 1 | 8 | 18:19 | -1 | 16 |
| 18 |
|
Sarmiento de Junín | 14 | 4 | 4 | 6 | 12:16 | -4 | 16 |
| 19 |
|
Newell's Old Boys | 14 | 4 | 4 | 6 | 16:21 | -5 | 16 |
| 20 |
|
Atlético Tucumán | 14 | 4 | 4 | 6 | 12:18 | -6 | 16 |
| 21 |
|
Patronato de Paraná | 14 | 3 | 6 | 5 | 10:14 | -4 | 15 |
| 22 |
|
Banfield | 14 | 2 | 8 | 4 | 10:13 | -3 | 14 |
| 23 |
|
Platense | 14 | 2 | 7 | 5 | 15:18 | -3 | 13 |
| 24 |
|
Aldosivi | 14 | 4 | 1 | 9 | 16:26 | -10 | 13 |
| 25 |
|
Central Córdoba SdE | 14 | 2 | 5 | 7 | 14:20 | -6 | 11 |
| 26 |
|
Arsenal de Sarandí | 14 | 2 | 5 | 7 | 6:20 | -14 | 11 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
