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| 13.09.2021 | 19:15 | Aldosivi | - | Godoy Cruz | 1:4 (0:0) | |
| 19:15 | Sarmiento de Junín | - | Huracán | 0:0 (0:0) | ||
| 21:30 | Independiente | - | Lanús | 0:1 (0:0) | ||
| 23:45 | San Lorenzo | - | Racing Club | 1:1 (0:0) | ||
| 14.09.2021 | 02:00 | Gimnasia de La Plata | - | Vélez Sarsfield | 0:0 (0:0) | |
| 19:15 | Talleres de Córdoba | - | Platense | 2:1 (0:0) | ||
| 21:30 | Arsenal de Sarandí | - | Colón de Santa Fe | 0:0 (0:0) | ||
| 23:45 | Central Córdoba SdE | - | Atlético Tucumán | 2:0 (0:0) | ||
| 15.09.2021 | 02:00 | Boca Juniors | - | Defensa y Justicia | 0:0 (0:0) | |
| 19:15 | Unión de Santa Fe | - | Estudiantes | 0:2 (0:2) | ||
| 21:30 | Argentinos Juniors | - | Patronato de Paraná | 1:1 (0:1) | ||
| 23:45 | Banfield | - | Rosario Central | 1:2 (1:1) | ||
| 16.09.2021 | 02:00 | Newell's Old Boys | - | River Plate | 1:4 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Talleres de Córdoba | 11 | 7 | 2 | 2 | 16:8 | 8 | 23 |
| 2 |
|
Lanús | 11 | 7 | 2 | 2 | 21:16 | 5 | 23 |
| 3 |
|
River Plate | 11 | 6 | 3 | 2 | 22:9 | 13 | 21 |
| 4 |
|
Estudiantes | 11 | 6 | 2 | 3 | 18:10 | 8 | 20 |
| 5 |
|
Independiente | 11 | 5 | 4 | 2 | 11:6 | 5 | 19 |
| 6 |
|
Racing Club | 11 | 4 | 6 | 1 | 9:2 | 7 | 18 |
| 7 |
|
Godoy Cruz | 11 | 5 | 1 | 5 | 18:16 | 2 | 16 |
| 8 |
|
Colón de Santa Fe | 11 | 4 | 4 | 3 | 9:14 | -5 | 16 |
| 9 |
|
Boca Juniors | 11 | 3 | 6 | 2 | 8:7 | 1 | 15 |
| 10 |
|
Atlético Tucumán | 11 | 4 | 3 | 4 | 11:14 | -3 | 15 |
| 11 |
|
Vélez Sarsfield | 11 | 3 | 5 | 3 | 13:6 | 7 | 14 |
| 12 |
|
Defensa y Justicia | 11 | 3 | 5 | 3 | 12:10 | 2 | 14 |
| 13 |
|
Argentinos Juniors | 11 | 3 | 5 | 3 | 9:8 | 1 | 14 |
| 14 |
|
Patronato de Paraná | 11 | 3 | 5 | 3 | 9:10 | -1 | 14 |
| 15 |
|
Rosario Central | 11 | 4 | 1 | 6 | 16:14 | 2 | 13 |
| 16 |
|
Huracán | 11 | 2 | 7 | 2 | 8:7 | 1 | 13 |
| 17 |
|
San Lorenzo | 11 | 3 | 4 | 4 | 10:13 | -3 | 13 |
| 18 |
|
Aldosivi | 11 | 4 | 1 | 6 | 12:18 | -6 | 13 |
| 19 |
|
Sarmiento de Junín | 11 | 3 | 3 | 5 | 10:14 | -4 | 12 |
| 20 |
|
Newell's Old Boys | 11 | 3 | 3 | 5 | 12:17 | -5 | 12 |
| 21 |
|
Unión de Santa Fe | 11 | 3 | 3 | 5 | 10:16 | -6 | 12 |
| 22 |
|
Central Córdoba SdE | 11 | 2 | 5 | 4 | 12:14 | -2 | 11 |
| 23 |
|
Gimnasia de La Plata | 11 | 2 | 5 | 4 | 7:13 | -6 | 11 |
| 24 |
|
Platense | 11 | 2 | 4 | 5 | 14:17 | -3 | 10 |
| 25 |
|
Banfield | 11 | 1 | 6 | 4 | 8:13 | -5 | 9 |
| 26 |
|
Arsenal de Sarandí | 11 | 1 | 5 | 5 | 5:18 | -13 | 8 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
