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| 25.02.2022 | 23:10 | Deportivo Morón | - | Defensores de Belgrano | 1:1 (0:1) | |
| 26.02.2022 | 01:30 | Estudiantes de Río Cuarto | - | Tristan Suárez | 1:1 (0:1) | |
| 21:00 | All Boys | - | Chaco For Ever | 2:2 (1:2) | ||
| 21:00 | Deportivo Madryn | - | San Martín de Tucumán | 1:2 (0:1) | ||
| 21:00 | Gimnasia de Jujuy | - | Guillermo Brown | 3:1 (2:0) | ||
| 23:05 | Nueva Chicago | - | Sacachispas | 1:1 (1:1) | ||
| 27.02.2022 | 21:00 | Deportivo Maipú | - | Mitre de SdE | 1:0 (0:0) | |
| 21:00 | Flandria | - | Chacarita Juniors | 1:2 (1:2) | ||
| 21:00 | Villa Dálmine | - | Ramón Santamarina | 0:3 (0:2) | ||
| 21:30 | Gimnasia de Mendoza | - | San Telmo | 3:0 (2:0) | ||
| 23:00 | Güemes de SdE | - | San Martín de San Juan | 1:1 (1:1) | ||
| 28.02.2022 | 00:00 | Belgrano de Córdoba | - | Estudiantes de Caseros | 2:1 (0:1) | |
| 01:30 | Temperley | - | Brown de Adrogué | 0:1 (0:0) | ||
| 21:00 | Deportivo Riestra | - | Atlanta | 1:0 (1:0) | ||
| 23:10 | Almagro | - | Instituto de Córdoba | 0:1 (0:1) | ||
| 01.03.2022 | Almirante Brown | - | Atlético Rafaela | 1:0 (0:0) | ||
| 00:00 | Alvarado | - | Agropecuario Argentino | 0:0 (0:0) | ||
| 01:10 | Quilmes | - | Ferro Carril Oeste | 2:1 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 3 | 3 | 0 | 0 | 4:1 | 3 | 9 |
| 2 |
|
Brown de Adrogué | 3 | 2 | 1 | 0 | 7:3 | 4 | 7 |
| 3 |
|
Deportivo Riestra | 3 | 2 | 1 | 0 | 3:0 | 3 | 7 |
| 4 |
|
All Boys | 3 | 2 | 1 | 0 | 4:2 | 2 | 7 |
|
San Martín de Tucumán | 3 | 2 | 1 | 0 | 4:2 | 2 | 7 | |
| 6 |
|
Deportivo Maipú | 3 | 2 | 1 | 0 | 3:1 | 2 | 7 |
| 7 |
|
Almirante Brown | 3 | 2 | 0 | 1 | 6:5 | 1 | 6 |
|
Guillermo Brown | 3 | 2 | 0 | 1 | 6:5 | 1 | 6 | |
| 9 |
|
Almagro | 3 | 2 | 0 | 1 | 3:2 | 1 | 6 |
| 10 |
|
Gimnasia de Jujuy | 3 | 1 | 2 | 0 | 6:4 | 2 | 5 |
| 11 |
|
Chaco For Ever | 3 | 1 | 2 | 0 | 4:3 | 1 | 5 |
| 12 |
|
Estudiantes de Río Cuarto | 3 | 1 | 2 | 0 | 3:2 | 1 | 5 |
| 13 |
|
Instituto de Córdoba | 3 | 1 | 2 | 0 | 2:1 | 1 | 5 |
| 14 |
|
Independiente Rivadavia | 2 | 1 | 1 | 0 | 2:1 | 1 | 4 |
| 15 |
|
Deportivo Madryn | 3 | 1 | 1 | 1 | 3:3 | 0 | 4 |
| 16 |
|
San Martín de San Juan | 3 | 1 | 1 | 1 | 2:2 | 0 | 4 |
| 17 |
|
Chacarita Juniors | 3 | 1 | 1 | 1 | 4:5 | -1 | 4 |
| 18 |
|
Gimnasia de Mendoza | 3 | 1 | 0 | 2 | 3:2 | 1 | 3 |
| 19 |
|
Atlanta | 3 | 1 | 0 | 2 | 3:3 | 0 | 3 |
|
Ramón Santamarina | 3 | 1 | 0 | 2 | 3:3 | 0 | 3 | |
|
Temperley | 3 | 1 | 0 | 2 | 3:3 | 0 | 3 | |
| 22 |
|
Quilmes | 2 | 1 | 0 | 1 | 2:2 | 0 | 3 |
|
Tristan Suárez | 3 | 0 | 3 | 0 | 2:2 | 0 | 3 | |
| 24 |
|
Alvarado | 3 | 0 | 3 | 0 | 1:1 | 0 | 3 |
|
Deportivo Morón | 3 | 0 | 3 | 0 | 1:1 | 0 | 3 | |
| 26 |
|
Ferro Carril Oeste | 3 | 1 | 0 | 2 | 2:3 | -1 | 3 |
| 27 |
|
Estudiantes de Caseros | 3 | 0 | 2 | 1 | 2:3 | -1 | 2 |
|
Sacachispas | 3 | 0 | 2 | 1 | 2:3 | -1 | 2 | |
| 29 |
|
Nueva Chicago | 3 | 0 | 2 | 1 | 1:2 | -1 | 2 |
| 30 |
|
Güemes de SdE | 3 | 0 | 2 | 1 | 3:5 | -2 | 2 |
| 31 |
|
Defensores de Belgrano | 3 | 0 | 2 | 1 | 2:4 | -2 | 2 |
| 32 |
|
Atlético Rafaela | 3 | 0 | 1 | 2 | 1:3 | -2 | 1 |
|
Mitre de SdE | 3 | 0 | 1 | 2 | 1:3 | -2 | 1 | |
| 34 |
|
Agropecuario Argentino | 3 | 0 | 1 | 2 | 0:2 | -2 | 1 |
| 35 |
|
San Telmo | 2 | 0 | 1 | 1 | 1:4 | -3 | 1 |
| 36 |
|
Flandria | 3 | 0 | 1 | 2 | 2:6 | -4 | 1 |
|
Villa Dálmine | 3 | 0 | 1 | 2 | 2:6 | -4 | 1 | |
| Promotion | |
| Play-off | |
| Play-off | |
| Relégation |
