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| 18.06.2022 | 02:10 | Ramón Santamarina | - | Instituto de Córdoba | 0:4 (0:2) | |
| 19:10 | All Boys | - | Nueva Chicago | 3:0 (0:0) | ||
| 20:00 | Estudiantes de Caseros | - | Sacachispas | 1:1 (0:0) | ||
| 20:30 | Almirante Brown | - | Deportivo Morón | 1:1 (1:0) | ||
| 20:30 | Deportivo Riestra | - | Alvarado | 3:0 (1:0) | ||
| 20:30 | Gimnasia de Mendoza | - | Deportivo Maipú | 1:1 (1:1) | ||
| 20:30 | Villa Dálmine | - | Deportivo Madryn | 3:3 (3:1) | ||
| 21:00 | Atlético Rafaela | - | Agropecuario Argentino | 2:2 (2:2) | ||
| 23:10 | Chaco For Ever | - | Independiente Rivadavia | 1:1 (1:0) | ||
| 19.06.2022 | 01:10 | Chacarita Juniors | - | San Martín de Tucumán | 0:0 (0:0) | |
| 16:00 | San Martín de San Juan | - | Ferro Carril Oeste | 1:0 (0:0) | ||
| 18:45 | San Telmo | - | Quilmes | 3:2 (2:2) | ||
| 20:00 | Gimnasia de Jujuy | - | Temperley | 3:0 (2:0) | ||
| 20:00 | Guillermo Brown | - | Tristan Suárez | 1:0 (0:0) | ||
| 20:50 | Belgrano de Córdoba | - | Estudiantes de Río Cuarto | 0:0 (0:0) | ||
| 20.06.2022 | 00:00 | Güemes de SdE | - | Almagro | 1:2 (1:0) | |
| 20:00 | Atlanta | - | Mitre de SdE | 0:1 (0:1) | ||
| 20:30 | Brown de Adrogué | - | Defensores de Belgrano | 0:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 19 | 13 | 4 | 2 | 24:11 | 13 | 43 |
| 2 |
|
San Martín de Tucumán | 19 | 10 | 7 | 2 | 24:14 | 10 | 37 |
| 3 |
|
Brown de Adrogué | 20 | 9 | 8 | 3 | 26:18 | 8 | 35 |
| 4 |
|
All Boys | 19 | 8 | 10 | 1 | 27:14 | 13 | 34 |
| 5 |
|
Instituto de Córdoba | 19 | 9 | 7 | 3 | 24:14 | 10 | 34 |
| 6 |
|
Almagro | 20 | 9 | 5 | 6 | 19:19 | 0 | 32 |
| 7 |
|
Gimnasia de Mendoza | 19 | 8 | 7 | 4 | 23:12 | 11 | 31 |
| 8 |
|
Guillermo Brown | 20 | 9 | 4 | 7 | 20:17 | 3 | 31 |
| 9 |
|
Independiente Rivadavia | 19 | 8 | 5 | 6 | 25:20 | 5 | 29 |
| 10 |
|
San Martín de San Juan | 20 | 8 | 5 | 7 | 25:21 | 4 | 29 |
| 11 |
|
Deportivo Maipú | 20 | 6 | 11 | 3 | 20:16 | 4 | 29 |
| 12 |
|
Estudiantes de Río Cuarto | 20 | 7 | 8 | 5 | 18:19 | -1 | 29 |
| 13 |
|
Chacarita Juniors | 20 | 7 | 7 | 6 | 31:26 | 5 | 28 |
| 14 |
|
Estudiantes de Caseros | 20 | 7 | 7 | 6 | 18:18 | 0 | 28 |
| 15 |
|
Deportivo Madryn | 20 | 6 | 9 | 5 | 27:22 | 5 | 27 |
| 16 |
|
Chaco For Ever | 20 | 5 | 11 | 4 | 23:18 | 5 | 26 |
| 17 |
|
Agropecuario Argentino | 19 | 5 | 11 | 3 | 20:15 | 5 | 26 |
| 18 |
|
Quilmes | 19 | 6 | 7 | 6 | 26:24 | 2 | 25 |
| 19 |
|
Deportivo Riestra | 19 | 5 | 10 | 4 | 15:15 | 0 | 25 |
| 20 |
|
Ferro Carril Oeste | 19 | 6 | 7 | 6 | 18:20 | -2 | 25 |
| 21 |
|
Defensores de Belgrano | 19 | 5 | 9 | 5 | 18:19 | -1 | 24 |
| 22 |
|
Nueva Chicago | 20 | 5 | 9 | 6 | 21:23 | -2 | 24 |
| 23 |
|
Gimnasia de Jujuy | 19 | 6 | 6 | 7 | 20:23 | -3 | 24 |
| 24 |
|
Alvarado | 20 | 6 | 6 | 8 | 20:31 | -11 | 24 |
| 25 |
|
Mitre de SdE | 19 | 5 | 7 | 7 | 21:21 | 0 | 22 |
| 26 |
|
Deportivo Morón | 20 | 4 | 10 | 6 | 12:12 | 0 | 22 |
| 27 |
|
Almirante Brown | 19 | 4 | 9 | 6 | 20:24 | -4 | 21 |
| 28 |
|
Sacachispas | 19 | 3 | 11 | 5 | 17:19 | -2 | 20 |
| 29 |
|
Atlanta | 20 | 4 | 8 | 8 | 18:22 | -4 | 20 |
| 30 |
|
Flandria | 19 | 4 | 7 | 8 | 21:25 | -4 | 19 |
| 31 |
|
Güemes de SdE | 19 | 4 | 7 | 8 | 13:17 | -4 | 19 |
| 32 |
|
Temperley | 20 | 4 | 7 | 9 | 16:26 | -10 | 19 |
| 33 |
|
San Telmo | 19 | 4 | 7 | 8 | 20:31 | -11 | 19 |
| 34 |
|
Atlético Rafaela | 20 | 3 | 9 | 8 | 19:21 | -2 | 18 |
| 35 |
|
Villa Dálmine | 19 | 2 | 10 | 7 | 21:30 | -9 | 16 |
| 36 |
|
Tristan Suárez | 19 | 2 | 7 | 10 | 18:29 | -11 | 13 |
| 37 |
|
Ramón Santamarina | 20 | 1 | 7 | 12 | 12:34 | -22 | 10 |
| Promotion | |
| Play-off | |
| Play-off | |
| Relégation |
