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| 11.06.2022 | 00:10 | Nueva Chicago | - | Gimnasia de Mendoza | 1:1 (0:0) | |
| 20:00 | Instituto de Córdoba | - | Atlético Rafaela | 0:0 (0:0) | ||
| 20:10 | Tristan Suárez | - | Chacarita Juniors | 3:2 (2:1) | ||
| 20:30 | Flandria | - | Gimnasia de Jujuy | 0:0 (0:0) | ||
| 20:30 | Quilmes | - | Chaco For Ever | 2:0 (1:0) | ||
| 12.06.2022 | 19:00 | Mitre de SdE | - | Estudiantes de Caseros | 2:0 (1:0) | |
| 19:05 | Deportivo Madryn | - | Belgrano de Córdoba | 1:1 (1:0) | ||
| 20:00 | Deportivo Maipú | - | San Telmo | 2:0 (1:0) | ||
| 20:30 | Deportivo Morón | - | Villa Dálmine | 1:0 (0:0) | ||
| 20:30 | Sacachispas | - | Ramón Santamarina | 2:1 (0:0) | ||
| 21:00 | Alvarado | - | Güemes de SdE | 2:1 (1:0) | ||
| 21:00 | Estudiantes de Río Cuarto | - | Deportivo Riestra | 2:0 (0:0) | ||
| 21:10 | Temperley | - | Almirante Brown | 1:1 (0:1) | ||
| 23:10 | Almagro | - | All Boys | 0:0 (0:0) | ||
| 13.06.2022 | 23:30 | Agropecuario Argentino | - | Guillermo Brown | 1:1 (0:0) | |
| 14.06.2022 | 01:00 | Independiente Rivadavia | - | San Martín de San Juan | 0:0 (0:0) | |
| 01:10 | San Martín de Tucumán | - | Brown de Adrogué | 2:1 (1:0) | ||
| 15.06.2022 | 02:10 | Ferro Carril Oeste | - | Atlanta | 1:0 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 18 | 13 | 3 | 2 | 24:11 | 13 | 42 |
| 2 |
|
San Martín de Tucumán | 18 | 10 | 6 | 2 | 24:14 | 10 | 36 |
| 3 |
|
Brown de Adrogué | 19 | 9 | 7 | 3 | 26:18 | 8 | 34 |
| 4 |
|
All Boys | 18 | 7 | 10 | 1 | 24:14 | 10 | 31 |
| 5 |
|
Instituto de Córdoba | 18 | 8 | 7 | 3 | 20:14 | 6 | 31 |
| 6 |
|
Gimnasia de Mendoza | 18 | 8 | 6 | 4 | 22:11 | 11 | 30 |
| 7 |
|
Almagro | 19 | 8 | 5 | 6 | 17:18 | -1 | 29 |
| 8 |
|
Independiente Rivadavia | 18 | 8 | 4 | 6 | 24:19 | 5 | 28 |
| 9 |
|
Deportivo Maipú | 19 | 6 | 10 | 3 | 19:15 | 4 | 28 |
| 10 |
|
Guillermo Brown | 19 | 8 | 4 | 7 | 19:17 | 2 | 28 |
| 11 |
|
Estudiantes de Río Cuarto | 19 | 7 | 7 | 5 | 18:19 | -1 | 28 |
| 12 |
|
Chacarita Juniors | 19 | 7 | 6 | 6 | 31:26 | 5 | 27 |
| 13 |
|
Estudiantes de Caseros | 19 | 7 | 6 | 6 | 17:17 | 0 | 27 |
| 14 |
|
Deportivo Madryn | 19 | 6 | 8 | 5 | 24:19 | 5 | 26 |
| 15 |
|
San Martín de San Juan | 19 | 7 | 5 | 7 | 24:21 | 3 | 26 |
| 16 |
|
Chaco For Ever | 19 | 5 | 10 | 4 | 22:17 | 5 | 25 |
| 17 |
|
Agropecuario Argentino | 18 | 5 | 10 | 3 | 18:13 | 5 | 25 |
| 18 |
|
Quilmes | 18 | 6 | 7 | 5 | 24:21 | 3 | 25 |
| 19 |
|
Ferro Carril Oeste | 18 | 6 | 7 | 5 | 18:19 | -1 | 25 |
| 20 |
|
Nueva Chicago | 19 | 5 | 9 | 5 | 21:20 | 1 | 24 |
| 21 |
|
Alvarado | 19 | 6 | 6 | 7 | 20:28 | -8 | 24 |
| 22 |
|
Defensores de Belgrano | 18 | 5 | 8 | 5 | 18:19 | -1 | 23 |
| 23 |
|
Deportivo Riestra | 18 | 4 | 10 | 4 | 12:15 | -3 | 22 |
| 24 |
|
Deportivo Morón | 19 | 4 | 9 | 6 | 11:11 | 0 | 21 |
| 25 |
|
Gimnasia de Jujuy | 18 | 5 | 6 | 7 | 17:23 | -6 | 21 |
| 26 |
|
Atlanta | 19 | 4 | 8 | 7 | 18:21 | -3 | 20 |
| 27 |
|
Almirante Brown | 18 | 4 | 8 | 6 | 19:23 | -4 | 20 |
| 28 |
|
Mitre de SdE | 18 | 4 | 7 | 7 | 20:21 | -1 | 19 |
| 29 |
|
Sacachispas | 18 | 3 | 10 | 5 | 16:18 | -2 | 19 |
| 30 |
|
Güemes de SdE | 18 | 4 | 7 | 7 | 12:15 | -3 | 19 |
| 31 |
|
Flandria | 19 | 4 | 7 | 8 | 21:25 | -4 | 19 |
| 32 |
|
Temperley | 19 | 4 | 7 | 8 | 16:23 | -7 | 19 |
| 33 |
|
Atlético Rafaela | 19 | 3 | 8 | 8 | 17:19 | -2 | 17 |
| 34 |
|
San Telmo | 18 | 3 | 7 | 8 | 17:29 | -12 | 16 |
| 35 |
|
Villa Dálmine | 18 | 2 | 9 | 7 | 18:27 | -9 | 15 |
| 36 |
|
Tristan Suárez | 18 | 2 | 7 | 9 | 18:28 | -10 | 13 |
| 37 |
|
Ramón Santamarina | 19 | 1 | 7 | 11 | 12:30 | -18 | 10 |
| Promotion | |
| Play-off | |
| Play-off | |
| Relégation |
