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| 06.05.2022 | 20:30 | San Telmo | - | Deportivo Madryn | 2:1 (1:0) | |
| 07.05.2022 | 02:10 | Atlanta | - | Almagro | 1:1 (1:1) | |
| 20:30 | Defensores de Belgrano | - | Sacachispas | 1:1 (1:0) | ||
| 20:30 | Deportivo Riestra | - | Gimnasia de Jujuy | 0:4 (0:2) | ||
| 21:00 | San Martín de San Juan | - | Alvarado | 0:0 (0:0) | ||
| 23:15 | Estudiantes de Caseros | - | Nueva Chicago | 1:0 (0:0) | ||
| 08.05.2022 | 00:00 | Atlético Rafaela | - | Quilmes | 1:2 (0:0) | |
| 00:00 | Tristan Suárez | - | Agropecuario Argentino | 0:1 (0:0) | ||
| 00:05 | Belgrano de Córdoba | - | Almirante Brown | 1:0 (0:0) | ||
| 16:00 | Brown de Adrogué | - | Mitre de SdE | 0:3 (0:1) | ||
| 20:00 | Guillermo Brown | - | Independiente Rivadavia | 3:2 (1:0) | ||
| 21:00 | Chaco For Ever | - | Estudiantes de Río Cuarto | 3:0 (1:0) | ||
| 21:00 | Gimnasia de Mendoza | - | Deportivo Morón | 1:0 (1:0) | ||
| 23:35 | Chacarita Juniors | - | Ferro Carril Oeste | 1:1 (0:0) | ||
| 09.05.2022 | 00:00 | Güemes de SdE | - | Flandria | 0:0 (0:0) | |
| 10.05.2022 | 00:10 | All Boys | - | Temperley | 2:0 (2:0) | |
| 01:30 | Ramón Santamarina | - | Deportivo Maipú | 0:0 (0:0) | ||
| 02:10 | San Martín de Tucumán | - | Instituto de Córdoba | 0:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 13 | 11 | 1 | 1 | 19:8 | 11 | 34 |
| 2 |
|
San Martín de Tucumán | 14 | 8 | 4 | 2 | 20:12 | 8 | 28 |
| 3 |
|
All Boys | 13 | 6 | 6 | 1 | 19:11 | 8 | 24 |
| 4 |
|
Brown de Adrogué | 14 | 6 | 6 | 2 | 19:13 | 6 | 24 |
| 5 |
|
Instituto de Córdoba | 13 | 6 | 6 | 1 | 15:9 | 6 | 24 |
| 6 |
|
Chacarita Juniors | 14 | 6 | 5 | 3 | 25:19 | 6 | 23 |
| 7 |
|
Gimnasia de Mendoza | 13 | 6 | 4 | 3 | 18:8 | 10 | 22 |
| 8 |
|
Deportivo Maipú | 14 | 5 | 7 | 2 | 13:10 | 3 | 22 |
| 9 |
|
Chaco For Ever | 14 | 4 | 9 | 1 | 17:11 | 6 | 21 |
| 10 |
|
Estudiantes de Caseros | 14 | 5 | 6 | 3 | 13:10 | 3 | 21 |
| 11 |
|
Estudiantes de Río Cuarto | 14 | 5 | 6 | 3 | 13:13 | 0 | 21 |
| 12 |
|
Agropecuario Argentino | 13 | 5 | 5 | 3 | 14:9 | 5 | 20 |
| 13 |
|
Deportivo Madryn | 14 | 5 | 5 | 4 | 20:16 | 4 | 20 |
| 14 |
|
Guillermo Brown | 14 | 6 | 2 | 6 | 14:14 | 0 | 20 |
| 15 |
|
Quilmes | 13 | 4 | 7 | 2 | 17:14 | 3 | 19 |
| 16 |
|
Deportivo Riestra | 13 | 4 | 7 | 2 | 10:10 | 0 | 19 |
| 17 |
|
Almagro | 14 | 5 | 4 | 5 | 13:16 | -3 | 19 |
| 18 |
|
San Martín de San Juan | 14 | 5 | 3 | 6 | 17:16 | 1 | 18 |
| 19 |
|
Almirante Brown | 14 | 4 | 6 | 4 | 16:16 | 0 | 18 |
| 20 |
|
Defensores de Belgrano | 14 | 4 | 6 | 4 | 15:17 | -2 | 18 |
| 21 |
|
Alvarado | 14 | 4 | 5 | 5 | 16:21 | -5 | 17 |
| 22 |
|
Nueva Chicago | 14 | 3 | 7 | 4 | 16:15 | 1 | 16 |
| 23 |
|
Atlanta | 14 | 3 | 7 | 4 | 15:16 | -1 | 16 |
| 24 |
|
Deportivo Morón | 14 | 3 | 6 | 5 | 9:9 | 0 | 15 |
| 25 |
|
Independiente Rivadavia | 13 | 4 | 3 | 6 | 16:19 | -3 | 15 |
| 26 |
|
San Telmo | 13 | 3 | 6 | 4 | 14:21 | -7 | 15 |
| 27 |
|
Mitre de SdE | 13 | 3 | 5 | 5 | 14:13 | 1 | 14 |
| 28 |
|
Atlético Rafaela | 14 | 3 | 5 | 6 | 14:14 | 0 | 14 |
| 29 |
|
Gimnasia de Jujuy | 14 | 3 | 5 | 6 | 13:20 | -7 | 14 |
| 30 |
|
Güemes de SdE | 13 | 2 | 6 | 5 | 8:12 | -4 | 12 |
| 31 |
|
Sacachispas | 13 | 1 | 8 | 4 | 11:14 | -3 | 11 |
| 32 |
|
Flandria | 14 | 2 | 5 | 7 | 17:22 | -5 | 11 |
| 33 |
|
Ferro Carril Oeste | 13 | 1 | 7 | 5 | 12:18 | -6 | 10 |
| 34 |
|
Tristan Suárez | 14 | 1 | 7 | 6 | 15:22 | -7 | 10 |
| 35 |
|
Villa Dálmine | 13 | 1 | 7 | 5 | 12:21 | -9 | 10 |
| 36 |
|
Temperley | 14 | 2 | 4 | 8 | 11:20 | -9 | 10 |
| 37 |
|
Ramón Santamarina | 14 | 1 | 6 | 7 | 10:21 | -11 | 9 |
| Promotion | |
| Play-off | |
| Play-off | |
| Relégation |
