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| 16.10.2021 | 00:10 | Defensores de Belgrano | - | Güemes de SdE | 1:0 (0:0) | |
| 02:10 | Atlético Rafaela | - | Barracas Central | 0:2 (0:1) | ||
| 20:00 | Brown de Adrogué | - | Gimnasia de Jujuy | 1:1 (1:0) | ||
| 21:00 | Ramón Santamarina | - | Almagro | 1:1 (1:1) | ||
| 17.10.2021 | 21:00 | San Martín de San Juan | - | Tristan Suárez | 4:0 (2:0) | |
| 21:00 | Guillermo Brown | - | Instituto de Córdoba | 1:1 (1:0) | ||
| 21:00 | Independiente Rivadavia | - | All Boys | 2:2 (2:0) | ||
| 18.10.2021 | 20:00 | San Telmo | - | Deportivo Morón | 0:1 (0:0) | |
| 20.10.2021 | 02:10 | Villa Dálmine | - | Ferro Carril Oeste | 1:1 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Barracas Central | 30 | 12 | 12 | 6 | 35:31 | 4 | 48 |
| 2 |
|
Ferro Carril Oeste | 30 | 11 | 12 | 7 | 36:26 | 10 | 45 |
| 3 |
|
Güemes de SdE | 30 | 11 | 12 | 7 | 32:28 | 4 | 45 |
| 4 |
|
Independiente Rivadavia | 30 | 10 | 14 | 6 | 39:36 | 3 | 44 |
| 5 |
|
Deportivo Morón | 30 | 13 | 5 | 12 | 30:31 | -1 | 44 |
| 6 |
|
Brown de Adrogué | 30 | 11 | 10 | 9 | 35:33 | 2 | 43 |
| 7 |
|
Gimnasia de Jujuy | 30 | 10 | 12 | 8 | 29:27 | 2 | 42 |
| 8 |
|
Almagro | 30 | 11 | 8 | 11 | 38:35 | 3 | 41 |
| 9 |
|
Defensores de Belgrano | 30 | 9 | 14 | 7 | 27:26 | 1 | 41 |
| 10 |
|
Tristan Suárez | 30 | 10 | 9 | 11 | 41:41 | 0 | 39 |
| 11 |
|
All Boys | 30 | 9 | 11 | 10 | 29:26 | 3 | 38 |
| 12 |
|
San Telmo | 30 | 8 | 13 | 9 | 33:40 | -7 | 37 |
| 13 |
|
San Martín de San Juan | 30 | 8 | 11 | 11 | 36:34 | 2 | 35 |
| 14 |
|
Villa Dálmine | 30 | 7 | 14 | 9 | 21:24 | -3 | 35 |
| 15 |
|
Instituto de Córdoba | 30 | 7 | 14 | 9 | 29:35 | -6 | 35 |
| 16 |
|
Atlético Rafaela | 30 | 8 | 10 | 12 | 29:31 | -2 | 34 |
| 17 |
|
Guillermo Brown | 30 | 5 | 15 | 10 | 23:30 | -7 | 30 |
| 18 |
|
Ramón Santamarina | 30 | 5 | 14 | 11 | 21:29 | -8 | 29 |
| Prochaine phase | |
| Play-off |
