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| 01.10.2021 | 20:30 | San Telmo | - | Almagro | 2:1 (1:0) | |
| 22:10 | Villa Dálmine | - | Güemes de SdE | 2:1 (1:0) | ||
| 02.10.2021 | 00:30 | Atlético Rafaela | - | Gimnasia de Jujuy | 2:0 (0:0) | |
| 16:30 | Barracas Central | - | All Boys | 2:1 (0:1) | ||
| 21:00 | Guillermo Brown | - | Tristan Suárez | 0:0 (0:0) | ||
| 22:00 | San Martín de San Juan | - | Deportivo Morón | 1:1 (0:0) | ||
| 03.10.2021 | 16:00 | Independiente Rivadavia | - | Instituto de Córdoba | 2:1 (0:1) | |
| 20:00 | Brown de Adrogué | - | Ferro Carril Oeste | 1:3 (1:0) | ||
| 04.10.2021 | 20:00 | Defensores de Belgrano | - | Ramón Santamarina | 0:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Barracas Central | 28 | 11 | 12 | 5 | 32:28 | 4 | 45 |
| 2 |
|
Güemes de SdE | 28 | 11 | 11 | 6 | 31:26 | 5 | 44 |
| 3 |
|
Ferro Carril Oeste | 28 | 10 | 11 | 7 | 32:23 | 9 | 41 |
| 4 |
|
Brown de Adrogué | 28 | 11 | 8 | 9 | 32:30 | 2 | 41 |
| 5 |
|
Deportivo Morón | 28 | 12 | 5 | 11 | 29:29 | 0 | 41 |
| 6 |
|
Independiente Rivadavia | 28 | 9 | 13 | 6 | 34:33 | 1 | 40 |
| 7 |
|
Tristan Suárez | 28 | 10 | 8 | 10 | 39:35 | 4 | 38 |
| 8 |
|
Defensores de Belgrano | 28 | 8 | 14 | 6 | 26:24 | 2 | 38 |
| 9 |
|
Gimnasia de Jujuy | 28 | 9 | 11 | 8 | 25:25 | 0 | 38 |
| 10 |
|
Almagro | 28 | 10 | 7 | 11 | 35:34 | 1 | 37 |
| 11 |
|
All Boys | 28 | 9 | 9 | 10 | 27:24 | 3 | 36 |
| 12 |
|
San Telmo | 28 | 8 | 12 | 8 | 32:38 | -6 | 36 |
| 13 |
|
Atlético Rafaela | 28 | 8 | 10 | 10 | 28:27 | 1 | 34 |
| 14 |
|
San Martín de San Juan | 28 | 7 | 11 | 10 | 30:31 | -1 | 32 |
| 15 |
|
Villa Dálmine | 28 | 6 | 13 | 9 | 18:23 | -5 | 31 |
| 16 |
|
Instituto de Córdoba | 28 | 6 | 13 | 9 | 26:33 | -7 | 31 |
| 17 |
|
Guillermo Brown | 28 | 5 | 14 | 9 | 21:26 | -5 | 29 |
| 18 |
|
Ramón Santamarina | 28 | 5 | 12 | 11 | 20:28 | -8 | 27 |
| Prochaine phase | |
| Play-off |
