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| 03.09.2021 | 20:30 | Barracas Central | - | Ferro Carril Oeste | 0:0 (0:0) | |
| 21:00 | San Martín de San Juan | - | Defensores de Belgrano | 1:0 (0:0) | ||
| 04.09.2021 | 00:10 | Atlético Rafaela | - | Güemes de SdE | 1:1 (0:0) | |
| 20:00 | Brown de Adrogué | - | Ramón Santamarina | 2:0 (1:0) | ||
| 20:00 | Gimnasia de Jujuy | - | All Boys | 1:0 (0:0) | ||
| 20:00 | Instituto de Córdoba | - | Tristan Suárez | 1:2 (1:1) | ||
| 20:00 | Villa Dálmine | - | San Telmo | 3:3 (0:3) | ||
| 20:30 | Guillermo Brown | - | Almagro | 1:0 (1:0) | ||
| 20:30 | Independiente Rivadavia | - | Deportivo Morón | 2:0 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Barracas Central | 24 | 10 | 10 | 4 | 27:23 | 4 | 40 |
| 2 |
|
Brown de Adrogué | 24 | 10 | 8 | 6 | 28:19 | 9 | 38 |
| 3 |
|
Güemes de SdE | 24 | 9 | 11 | 4 | 26:20 | 6 | 38 |
| 4 |
|
Independiente Rivadavia | 24 | 8 | 12 | 4 | 30:23 | 7 | 36 |
| 5 |
|
Deportivo Morón | 24 | 11 | 3 | 10 | 27:26 | 1 | 36 |
| 6 |
|
Tristan Suárez | 24 | 9 | 6 | 9 | 34:30 | 4 | 33 |
| 7 |
|
Defensores de Belgrano | 24 | 7 | 12 | 5 | 24:22 | 2 | 33 |
| 8 |
|
Ferro Carril Oeste | 24 | 8 | 9 | 7 | 22:21 | 1 | 33 |
| 9 |
|
Gimnasia de Jujuy | 24 | 8 | 9 | 7 | 21:21 | 0 | 33 |
| 10 |
|
Almagro | 24 | 9 | 6 | 9 | 27:29 | -2 | 33 |
| 11 |
|
San Martín de San Juan | 24 | 7 | 8 | 9 | 28:28 | 0 | 29 |
| 12 |
|
San Telmo | 24 | 6 | 11 | 7 | 28:34 | -6 | 29 |
| 13 |
|
Instituto de Córdoba | 24 | 5 | 13 | 6 | 23:27 | -4 | 28 |
| 14 |
|
All Boys | 24 | 6 | 9 | 9 | 19:21 | -2 | 27 |
| 15 |
|
Atlético Rafaela | 24 | 6 | 8 | 10 | 23:25 | -2 | 26 |
| 16 |
|
Ramón Santamarina | 24 | 5 | 10 | 9 | 20:25 | -5 | 25 |
| 17 |
|
Guillermo Brown | 24 | 4 | 12 | 8 | 18:25 | -7 | 24 |
| 18 |
|
Villa Dálmine | 24 | 3 | 13 | 8 | 13:19 | -6 | 22 |
| Prochaine phase | |
| Play-off |
