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| 19.02.2019 | 14:00 | Dinamo Zagreb | - | Lokomotiv Moskva | 5:4 (1:0, 1:1) tab | |
| 16:00 | Hertha BSC | - | Paris Saint-Germain | 2:1 (0:1) | ||
| 18:00 | Chelsea FC | - | AS Monaco | 3:1 (1:0) | ||
| 18:00 | PAOK Saloniki | - | Tottenham Hotspur | 0:1 (0:1) | ||
| 20.02.2019 | 13:00 | Dinamo Kiev | - | Juventus | 3:0 (1:0) | |
| 14:00 | FC Midtjylland | - | AS Roma | 4:2 (1:1, 1:1) tab | ||
| 16:00 | Montpellier HSC | - | SL Benfica | 2:1 (0:0) | ||
| 16:00 | Sigma Olomouc | - | Olympique Lyonnais | 0:2 (0:1) |
