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| 15.10.2021 | 19:00 | Karlsruher SC | - | Stuttgarter Kickers | 0:0 (0:0) | |
| 16.10.2021 | 11:00 | Eintracht Frankfurt | - | Bayern München | 2:3 (2:1) | |
| 11:00 | FC Ingolstadt 04 | - | SpVgg Unterhaching | 1:2 (0:1) | ||
| 12:00 | 1. FC Nürnberg | - | Kickers Offenbach | 3:0 (2:0) | ||
| 13:00 | 1899 Hoffenheim | - | SSV Ulm 1846 | 5:2 (1:1) | ||
| 13:00 | VfB Stuttgart | - | FC Augsburg | 1:1 (0:0) | ||
| 17.10.2021 | 11:00 | Hessen Kassel | - | SC Freiburg | 0:5 (0:2) | |
| 11:00 | 1. FSV Mainz 05 | - | SV Darmstadt 98 | 0:0 (0:0) | ||
| 13:00 | FC-Astoria Walldorf | - | 1. FC Kaiserslautern | 4:2 (1:1) | ||
| 14:00 | SpVgg Greuther Fürth | - | 1. FC Heidenheim 1846 | 0:3 (0:2) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Nürnberg | 7 | 6 | 0 | 1 | 18:9 | 9 | 18 |
| 2 |
|
1899 Hoffenheim | 7 | 5 | 1 | 1 | 32:15 | 17 | 16 |
| 3 |
|
VfB Stuttgart | 7 | 5 | 1 | 1 | 21:7 | 14 | 16 |
| 4 |
|
SpVgg Unterhaching | 7 | 4 | 2 | 1 | 12:8 | 4 | 14 |
| 5 |
|
Eintracht Frankfurt | 7 | 4 | 1 | 2 | 21:9 | 12 | 13 |
| 6 |
|
1. FC Heidenheim 1846 | 7 | 4 | 1 | 2 | 15:8 | 7 | 13 |
| 7 |
|
FC Augsburg | 6 | 4 | 1 | 1 | 10:6 | 4 | 13 |
| 8 |
|
SV Darmstadt 98 | 7 | 3 | 2 | 2 | 7:13 | -6 | 11 |
| 9 |
|
1. FSV Mainz 05 | 7 | 3 | 1 | 3 | 21:12 | 9 | 10 |
| 10 |
|
SC Freiburg | 7 | 3 | 1 | 3 | 18:17 | 1 | 10 |
| 11 |
|
Bayern München | 6 | 3 | 0 | 3 | 14:11 | 3 | 9 |
| 12 |
|
Karlsruher SC | 6 | 1 | 4 | 1 | 8:7 | 1 | 7 |
| 13 |
|
FC Ingolstadt 04 | 6 | 2 | 1 | 3 | 12:12 | 0 | 7 |
| 14 |
|
Stuttgarter Kickers | 7 | 2 | 1 | 4 | 10:20 | -10 | 7 |
| 15 |
|
SSV Ulm 1846 | 6 | 2 | 0 | 4 | 7:12 | -5 | 6 |
| 16 |
|
SpVgg Greuther Fürth | 7 | 1 | 3 | 3 | 6:11 | -5 | 6 |
| 17 |
|
Kickers Offenbach | 7 | 2 | 0 | 5 | 8:19 | -11 | 6 |
| 18 |
|
1. FC Kaiserslautern | 7 | 2 | 0 | 5 | 15:27 | -12 | 6 |
| 19 |
|
FC-Astoria Walldorf | 6 | 1 | 2 | 3 | 9:16 | -7 | 5 |
| 20 |
|
1. FC Saarbrücken | 6 | 1 | 0 | 5 | 5:15 | -10 | 3 |
| 21 |
|
Hessen Kassel | 7 | 1 | 0 | 6 | 4:19 | -15 | 3 |
| Play-off | |
| Relégation |
