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| 25.09.2021 | 11:00 | 1. FC Saarbrücken | - | Bayern München | 1:5 (0:4) | |
| 12:00 | 1899 Hoffenheim | - | Kickers Offenbach | 6:1 (4:1) | ||
| 12:00 | Eintracht Frankfurt | - | SC Freiburg | 4:0 (2:0) | ||
| 12:00 | VfB Stuttgart | - | SSV Ulm 1846 | 3:1 (1:0) | ||
| 13:30 | 1. FC Nürnberg | - | SV Darmstadt 98 | 1:2 (0:1) | ||
| 26.09.2021 | 11:00 | Hessen Kassel | - | 1. FC Heidenheim 1846 | 0:5 (0:1) | |
| 11:00 | FC-Astoria Walldorf | - | FC Ingolstadt 04 | 0:2 (0:2) | ||
| 11:00 | 1. FSV Mainz 05 | - | 1. FC Kaiserslautern | 7:1 (4:0) | ||
| 13:00 | SpVgg Greuther Fürth | - | Stuttgarter Kickers | 3:1 (2:0) | ||
| 13.11.2021 | 15:00 | Karlsruher SC | - | SpVgg Unterhaching | 0:0 (0:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1899 Hoffenheim | 5 | 4 | 0 | 1 | 24:10 | 14 | 12 |
| 2 |
|
VfB Stuttgart | 5 | 4 | 0 | 1 | 16:5 | 11 | 12 |
| 3 |
|
1. FC Nürnberg | 5 | 4 | 0 | 1 | 13:8 | 5 | 12 |
| 4 |
|
FC Augsburg | 4 | 4 | 0 | 0 | 9:4 | 5 | 12 |
| 5 |
|
Eintracht Frankfurt | 5 | 3 | 1 | 1 | 17:5 | 12 | 10 |
| 6 |
|
1. FC Heidenheim 1846 | 5 | 3 | 1 | 1 | 11:6 | 5 | 10 |
| 7 |
|
1. FSV Mainz 05 | 5 | 3 | 0 | 2 | 20:10 | 10 | 9 |
| 8 |
|
SV Darmstadt 98 | 5 | 3 | 0 | 2 | 7:13 | -6 | 9 |
| 9 |
|
SpVgg Unterhaching | 5 | 2 | 2 | 1 | 6:4 | 2 | 8 |
| 10 |
|
FC Ingolstadt 04 | 5 | 2 | 1 | 2 | 11:10 | 1 | 7 |
| 11 |
|
Bayern München | 4 | 2 | 0 | 2 | 10:5 | 5 | 6 |
| 12 |
|
Karlsruher SC | 4 | 1 | 3 | 0 | 5:3 | 2 | 6 |
| 13 |
|
SSV Ulm 1846 | 4 | 2 | 0 | 2 | 4:5 | -1 | 6 |
| 14 |
|
SC Freiburg | 5 | 2 | 0 | 3 | 10:14 | -4 | 6 |
| 15 |
|
SpVgg Greuther Fürth | 5 | 1 | 2 | 2 | 6:8 | -2 | 5 |
| 16 |
|
Hessen Kassel | 5 | 1 | 0 | 4 | 4:11 | -7 | 3 |
| 17 |
|
1. FC Kaiserslautern | 5 | 1 | 0 | 4 | 9:20 | -11 | 3 |
| 18 |
|
Stuttgarter Kickers | 5 | 1 | 0 | 4 | 8:19 | -11 | 3 |
| 19 |
|
Kickers Offenbach | 5 | 1 | 0 | 4 | 5:16 | -11 | 3 |
| 20 |
|
FC-Astoria Walldorf | 4 | 0 | 2 | 2 | 2:10 | -8 | 2 |
| 21 |
|
1. FC Saarbrücken | 5 | 0 | 0 | 5 | 4:15 | -11 | 0 |
| Play-off | |
| Relégation |
