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| 02.04.2022 | 11:00 | SC Freiburg | - | 1. FC Heidenheim 1846 | 4:1 (0:1) | |
| 12:00 | 1899 Hoffenheim | - | Karlsruher SC | 1:1 (1:0) | ||
| 13:00 | Eintracht Frankfurt | - | FC-Astoria Walldorf | 1:0 (0:0) | ||
| 13:00 | VfB Stuttgart | - | FC Ingolstadt 04 | 6:1 (3:0) | ||
| 03.04.2022 | 11:00 | 1. FC Saarbrücken | - | SpVgg Unterhaching | 2:1 (1:0) | |
| 11:00 | FC Augsburg | - | 1. FC Kaiserslautern | 4:3 (1:0) | ||
| 13:00 | Bayern München | - | Stuttgarter Kickers | 2:5 (1:3) | ||
| 05.04.2022 | 18:30 | 1. FC Nürnberg | - | SpVgg Greuther Fürth | 2:0 (0:0) | |
| 13.04.2022 | 19:00 | Hessen Kassel | - | 1. FSV Mainz 05 | 1:6 (0:3) | |
| 20.04.2022 | 11:00 | SSV Ulm 1846 | - | SV Darmstadt 98 | 0:2 (0:1) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VfB Stuttgart | 17 | 12 | 2 | 3 | 50:15 | 35 | 38 |
| 2 |
|
FC Augsburg | 17 | 11 | 4 | 2 | 48:29 | 19 | 37 |
| 3 |
|
1. FC Nürnberg | 17 | 12 | 1 | 4 | 36:23 | 13 | 37 |
| 4 |
|
Eintracht Frankfurt | 17 | 11 | 3 | 3 | 49:21 | 28 | 36 |
| 5 |
|
1. FSV Mainz 05 | 18 | 11 | 2 | 5 | 54:33 | 21 | 35 |
| 6 |
|
1899 Hoffenheim | 17 | 9 | 4 | 4 | 55:29 | 26 | 31 |
| 7 |
|
Bayern München | 17 | 9 | 2 | 6 | 52:27 | 25 | 29 |
| 8 |
|
SpVgg Unterhaching | 17 | 8 | 3 | 6 | 29:29 | 0 | 27 |
| 9 |
|
SV Darmstadt 98 | 17 | 7 | 5 | 5 | 25:25 | 0 | 26 |
| 10 |
|
1. FC Heidenheim 1846 | 17 | 7 | 4 | 6 | 30:24 | 6 | 25 |
| 11 |
|
SC Freiburg | 18 | 7 | 4 | 7 | 37:34 | 3 | 25 |
| 12 |
|
Karlsruher SC | 17 | 6 | 7 | 4 | 27:27 | 0 | 25 |
| 13 |
|
FC Ingolstadt 04 | 17 | 6 | 4 | 7 | 32:34 | -2 | 22 |
| 14 |
|
1. FC Kaiserslautern | 17 | 7 | 1 | 9 | 34:47 | -13 | 22 |
| 15 |
|
FC-Astoria Walldorf | 17 | 5 | 6 | 6 | 29:30 | -1 | 21 |
| 16 |
|
Stuttgarter Kickers | 17 | 6 | 2 | 9 | 32:45 | -13 | 20 |
| 17 |
|
SpVgg Greuther Fürth | 18 | 4 | 3 | 11 | 25:42 | -17 | 15 |
| 18 |
|
Kickers Offenbach | 17 | 4 | 2 | 11 | 20:42 | -22 | 14 |
| 19 |
|
1. FC Saarbrücken | 17 | 4 | 0 | 13 | 17:36 | -19 | 12 |
| 20 |
|
SSV Ulm 1846 | 17 | 3 | 1 | 13 | 21:46 | -25 | 10 |
| 21 |
|
Hessen Kassel | 17 | 1 | 0 | 16 | 7:71 | -64 | 3 |
| Play-off | |
| Relégation |
