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| 04.03.2022 | 18:00 | FC-Astoria Walldorf | - | VfB Stuttgart | 3:0 (1:0) | |
| 05.03.2022 | 11:00 | 1. FC Heidenheim 1846 | - | Kickers Offenbach | 0:0 (0:0) | |
| 11:00 | 1. FC Kaiserslautern | - | Bayern München | 2:2 (2:0) | ||
| 11:00 | FC Ingolstadt 04 | - | 1. FC Saarbrücken | 3:2 (2:1) | ||
| 12:00 | SV Darmstadt 98 | - | SC Freiburg | 3:2 (0:0) | ||
| 12:00 | 1. FSV Mainz 05 | - | 1899 Hoffenheim | 3:2 (3:1) | ||
| 13:00 | SpVgg Greuther Fürth | - | Hessen Kassel | 5:0 (3:0) | ||
| 13:00 | Karlsruher SC | - | Eintracht Frankfurt | 0:6 (0:3) | ||
| 06.03.2022 | 13:00 | Stuttgarter Kickers | - | SSV Ulm 1846 | 5:1 (4:1) | |
| 13:30 | SpVgg Unterhaching | - | FC Augsburg | 1:1 (0:1) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VfB Stuttgart | 16 | 11 | 2 | 3 | 44:14 | 30 | 35 |
| 2 |
|
FC Augsburg | 16 | 10 | 4 | 2 | 44:26 | 18 | 34 |
| 3 |
|
1. FC Nürnberg | 16 | 11 | 1 | 4 | 34:23 | 11 | 34 |
| 4 |
|
Eintracht Frankfurt | 16 | 10 | 3 | 3 | 48:21 | 27 | 33 |
| 5 |
|
1. FSV Mainz 05 | 17 | 10 | 2 | 5 | 48:32 | 16 | 32 |
| 6 |
|
1899 Hoffenheim | 16 | 9 | 3 | 4 | 54:28 | 26 | 30 |
| 7 |
|
Bayern München | 16 | 9 | 2 | 5 | 50:22 | 28 | 29 |
| 8 |
|
SpVgg Unterhaching | 16 | 8 | 3 | 5 | 28:27 | 1 | 27 |
| 9 |
|
1. FC Heidenheim 1846 | 16 | 7 | 4 | 5 | 29:20 | 9 | 25 |
| 10 |
|
Karlsruher SC | 16 | 6 | 6 | 4 | 26:26 | 0 | 24 |
| 11 |
|
SV Darmstadt 98 | 16 | 6 | 5 | 5 | 23:25 | -2 | 23 |
| 12 |
|
FC Ingolstadt 04 | 16 | 6 | 4 | 6 | 31:28 | 3 | 22 |
| 13 |
|
SC Freiburg | 17 | 6 | 4 | 7 | 33:33 | 0 | 22 |
| 14 |
|
1. FC Kaiserslautern | 16 | 7 | 1 | 8 | 31:43 | -12 | 22 |
| 15 |
|
FC-Astoria Walldorf | 16 | 5 | 6 | 5 | 29:29 | 0 | 21 |
| 16 |
|
Stuttgarter Kickers | 16 | 5 | 2 | 9 | 27:43 | -16 | 17 |
| 17 |
|
SpVgg Greuther Fürth | 17 | 4 | 3 | 10 | 25:40 | -15 | 15 |
| 18 |
|
Kickers Offenbach | 17 | 4 | 2 | 11 | 20:42 | -22 | 14 |
| 19 |
|
SSV Ulm 1846 | 16 | 3 | 1 | 12 | 21:44 | -23 | 10 |
| 20 |
|
1. FC Saarbrücken | 16 | 3 | 0 | 13 | 15:35 | -20 | 9 |
| 21 |
|
Hessen Kassel | 16 | 1 | 0 | 15 | 6:65 | -59 | 3 |
| Play-off | |
| Relégation |
