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| 25.02.2022 | 18:00 | VfB Stuttgart | - | Karlsruher SC | 0:1 (0:0) | |
| 26.02.2022 | 11:00 | Kickers Offenbach | - | SV Darmstadt 98 | 0:4 (0:1) | |
| 11:00 | Eintracht Frankfurt | - | 1. FSV Mainz 05 | 2:2 (1:0) | ||
| 11:00 | Bayern München | - | SpVgg Unterhaching | 3:0 (1:0) | ||
| 13:00 | SC Freiburg | - | Stuttgarter Kickers | 1:2 (0:2) | ||
| 13:00 | 1899 Hoffenheim | - | SpVgg Greuther Fürth | 3:0 (1:0) | ||
| 13:00 | FC Augsburg | - | FC Ingolstadt 04 | 3:2 (0:2) | ||
| 27.02.2022 | 14:00 | 1. FC Saarbrücken | - | FC-Astoria Walldorf | 2:3 (2:0) | |
| 14:00 | SSV Ulm 1846 | - | 1. FC Kaiserslautern | 0:1 (0:0) | ||
| 13.03.2022 | 11:00 | Hessen Kassel | - | 1. FC Nürnberg | 0:3 (0:2) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VfB Stuttgart | 15 | 11 | 2 | 2 | 44:11 | 33 | 35 |
| 2 |
|
1. FC Nürnberg | 16 | 11 | 1 | 4 | 34:23 | 11 | 34 |
| 3 |
|
FC Augsburg | 15 | 10 | 3 | 2 | 43:25 | 18 | 33 |
| 4 |
|
1899 Hoffenheim | 15 | 9 | 3 | 3 | 52:25 | 27 | 30 |
| 5 |
|
Eintracht Frankfurt | 15 | 9 | 3 | 3 | 42:21 | 21 | 30 |
| 6 |
|
1. FSV Mainz 05 | 16 | 9 | 2 | 5 | 45:30 | 15 | 29 |
| 7 |
|
Bayern München | 15 | 9 | 1 | 5 | 48:20 | 28 | 28 |
| 8 |
|
SpVgg Unterhaching | 15 | 8 | 2 | 5 | 27:26 | 1 | 26 |
| 9 |
|
1. FC Heidenheim 1846 | 15 | 7 | 3 | 5 | 29:20 | 9 | 24 |
| 10 |
|
Karlsruher SC | 15 | 6 | 6 | 3 | 26:20 | 6 | 24 |
| 11 |
|
SC Freiburg | 16 | 6 | 4 | 6 | 31:30 | 1 | 22 |
| 12 |
|
1. FC Kaiserslautern | 15 | 7 | 0 | 8 | 29:41 | -12 | 21 |
| 13 |
|
SV Darmstadt 98 | 15 | 5 | 5 | 5 | 20:23 | -3 | 20 |
| 14 |
|
FC Ingolstadt 04 | 15 | 5 | 4 | 6 | 28:26 | 2 | 19 |
| 15 |
|
FC-Astoria Walldorf | 15 | 4 | 6 | 5 | 26:29 | -3 | 18 |
| 16 |
|
Stuttgarter Kickers | 15 | 4 | 2 | 9 | 22:42 | -20 | 14 |
| 17 |
|
Kickers Offenbach | 16 | 4 | 1 | 11 | 20:42 | -22 | 13 |
| 18 |
|
SpVgg Greuther Fürth | 16 | 3 | 3 | 10 | 20:40 | -20 | 12 |
| 19 |
|
SSV Ulm 1846 | 15 | 3 | 1 | 11 | 20:39 | -19 | 10 |
| 20 |
|
1. FC Saarbrücken | 15 | 3 | 0 | 12 | 13:32 | -19 | 9 |
| 21 |
|
Hessen Kassel | 15 | 1 | 0 | 14 | 6:60 | -54 | 3 |
| Play-off | |
| Relégation |
