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| 26.11.2021 | 16:00 | Karlsruher SC | - | SC Freiburg | 1:1 (0:1) | |
| 27.11.2021 | 12:00 | 1899 Hoffenheim | - | VfB Stuttgart | 2:2 (1:0) | |
| 13:00 | 1. FC Nürnberg | - | FC Augsburg | 2:2 (1:2) | ||
| 13:00 | FC Ingolstadt 04 | - | 1. FC Heidenheim 1846 | 3:2 (2:1) | ||
| 14:00 | 1. FC Kaiserslautern | - | Stuttgarter Kickers | 5:3 (1:1) | ||
| 28.11.2021 | 11:00 | Hessen Kassel | - | 1. FC Saarbrücken | 0:2 (0:1) | |
| 11:00 | 1. FSV Mainz 05 | - | SSV Ulm 1846 | 3:2 (1:2) | ||
| 12:00 | FC-Astoria Walldorf | - | Kickers Offenbach | 5:0 (2:0) | ||
| 13:00 | SpVgg Greuther Fürth | - | Bayern München | 1:7 (0:3) | ||
| 29.01.2022 | 11:00 | SpVgg Unterhaching | - | SV Darmstadt 98 | 1:4 (0:4) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Nürnberg | 11 | 9 | 1 | 1 | 28:13 | 15 | 28 |
| 2 |
|
VfB Stuttgart | 10 | 7 | 2 | 1 | 27:9 | 18 | 23 |
| 3 |
|
1. FSV Mainz 05 | 11 | 7 | 1 | 3 | 34:15 | 19 | 22 |
| 4 |
|
1899 Hoffenheim | 11 | 6 | 3 | 2 | 40:23 | 17 | 21 |
| 5 |
|
FC Augsburg | 10 | 6 | 3 | 1 | 27:14 | 13 | 21 |
| 6 |
|
SpVgg Unterhaching | 10 | 6 | 2 | 2 | 18:13 | 5 | 20 |
| 7 |
|
Eintracht Frankfurt | 10 | 5 | 2 | 3 | 27:15 | 12 | 17 |
| 8 |
|
Bayern München | 10 | 5 | 1 | 4 | 30:15 | 15 | 16 |
| 9 |
|
SV Darmstadt 98 | 11 | 4 | 4 | 3 | 13:17 | -4 | 16 |
| 10 |
|
FC Ingolstadt 04 | 10 | 4 | 2 | 4 | 19:17 | 2 | 14 |
| 11 |
|
1. FC Heidenheim 1846 | 11 | 4 | 2 | 5 | 19:19 | 0 | 14 |
| 12 |
|
SC Freiburg | 11 | 4 | 2 | 5 | 21:25 | -4 | 14 |
| 13 |
|
FC-Astoria Walldorf | 10 | 3 | 4 | 3 | 19:18 | 1 | 13 |
| 14 |
|
Karlsruher SC | 10 | 2 | 6 | 2 | 14:16 | -2 | 12 |
| 15 |
|
SpVgg Greuther Fürth | 11 | 3 | 3 | 5 | 14:22 | -8 | 12 |
| 16 |
|
1. FC Kaiserslautern | 10 | 4 | 0 | 6 | 22:33 | -11 | 12 |
| 17 |
|
SSV Ulm 1846 | 10 | 3 | 0 | 7 | 15:21 | -6 | 9 |
| 18 |
|
Kickers Offenbach | 11 | 3 | 0 | 8 | 15:32 | -17 | 9 |
| 19 |
|
Stuttgarter Kickers | 11 | 2 | 2 | 7 | 16:32 | -16 | 8 |
| 20 |
|
1. FC Saarbrücken | 10 | 2 | 0 | 8 | 8:22 | -14 | 6 |
| 21 |
|
Hessen Kassel | 11 | 1 | 0 | 10 | 5:40 | -35 | 3 |
| Play-off | |
| Relégation |
